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Pumping Longevity with Science & Data
Recorded: Aug. 22, 2025 Duration: 1:51:21Space Recording
Full Transcription
Thank you. Good evening, everyone.
Hello, hello, hello. Thank you. It is working? Hello.
Welcome everyone.
I think we'll just wait a couple of more minutes for everyone to join.
Hello, yeah.
Yeah. for everyone to join. Hello, GM. GM.
Hi, Julian.
How you be?
I see them thumbs up.
I'm getting excited.
Yes.
Everybody's so quiet.
Okay, maybe we can just start because I also feel like this space is kind of overdue.
Super excited to be here with everyone.
Maybe everyone who is a Madrid can introduce themselves very quick.
Yeah, I mean, I might as well just go ahead and start.
I am obviously the intern and I look forward to this discussion.
Yeah, and I'm Professor Ticomita, I don't know if you can hear me well. I've also been part of the Nootropic STAO project and working on the Pino one lunch.
Oh yeah, yeah, yeah, yeah. We represent nootrophics now.
Anyways, on to the next.
GM, everybody of Pump Science here, excited to hear from the drug devs.
Yes. So maybe for a little bit of context, I think also from the molecule side now that
we're more connected with Pump Science and Pump Science tokens as well, we thought it
might be a good time to give everyone a little bit of space to also talk about the compounds, the warm trials that went on this week, all the craziness.
Yeah, super excited for everyone.
So maybe we can just start with some of the more obvious things. So there's a lot of talk about two specific compounds,
I would say, Omipa and Raptor.
So maybe the Omipa team wants to speak up a little bit.
Yeah. Do you hear me?
Yes.
Yeah, perfect.
Yeah, I'm Chris Kelpie and the founder of the Repamycin Longevit Lab.
We launched the lab in 2023 and last year we did a quite exciting discovery around a compound called Omepalasev.
a compound called omepalacib.
And the discovery was that we found that that specific compound
has life-extending properties.
And after that, we have studied it in worms,
and we have also done some experiments in mice.
We have also done some experiments in mice.
And when Palm Science contacted us
and asked if we had some interesting thing
to launch on our platform,
then we felt that Omepalasev is our leading candidate.
So of course we should launch that. And yeah, it has been quite hectic two weeks here.
Lots of things has happened
and it has been a great, great launch.
Yeah, definitely.
A lot of things have happened ever since.
And I think one of the key things you mentioned as well is how it outperformed rapamycin,
which is interesting because there's also rapamycin compounds on pump.science, right?
So maybe you can speak a little bit more about the WARM trials
and what it means if it outperforms another compound.
Yes, rapamycin, if we look at that compound, it's an mTOR inhibitor.
And mTOR inhibition when it comes to, for example,
inhibiting mTOR genetically and also through pharmaceutical interventions.
Then those things seem to work across multiple species.
And the thing when you inhibit mTOR, then you suppress the growth pathways.
And if we also look at many different longevity interventions
that exist out there, they also inhibit one or the other way
way growth promoting pathways.
growth promoting pathways.
But currently rapamycin is the gold standard intervention because it has the best data in
multiple species.
And if we look, for example, at omepalacib, which is a dual PI-freakines mTOR inhibitor,
it inhibits the growth promoting pathways
in a little bit broader perspective.
And we think that thanks to this broader targeting,
the broader targeting, then we achieve this outperforming effect in lifespan that we see.
And the best recorded lifespan effect that we have seen on Omipalasev, it's 63%. And if we compare it to rapamycin, it
has been quite long, seeing that it's 27%. So Omipalaseb doubles that.
So that makes it very, very exciting
drug to dig more into.
Yeah, and I think it was also great to see that it now
performed so well in the warm experiments.
And maybe you could just explain the next steps, because you also mentioned mouse trials that happened already.
Yeah, the thing is that during last week we got the warm experiments announced on Palm Science and that made Omipalletib the king of the pill on worm experiments.
And that means that Omipalletib is currently the best compound on the Palm Science platform when it comes to worm experiments. The next step here is that we are going to
conduct the experiments in flies and see how well this result translates to flies.
And after that we will go to mice experiments and after that we will do human clinical trials.
Yeah, very interesting. I think there is another death from another mTOR inhibitor compound here as well,
which is Raptor. So maybe Ethan, you could explain a little bit more about Raptor, what made you took
it on Chain, launched it on PumScience.
GMGM, everybody.
It's great to see all these beautiful DGens here assembled on a Friday in August.
So I'm Ethan.
I'm the dev behind Raptor.
And just a little bit about the backstory.
So I've been an mTOR worshiper for over 20 years.
And yes, while I do think in some ways there is no second best, I think rapamycin actually do well with Dan's partner or two.
And the rationale behind that is that mTOR or rapamycin obviously is the canonical mTOR
inhibitor.
And back when I was in graduate school 20 plus years ago, part of my thesis work was
to identify novel small molecules that could enhance or suppress the effects of rapamycin
with the idea of creating a cocktail that could suppress rapamycin's liabilities and
accentuate its positives.
So SMRT28, a lot of work has been done since I discovered it.
And for instance, the first paper came out about it in 2007. And what has become known is that
SMR28 boosts autophagy, but it does it via an mTOR independent pathway. And the target mechanism of
SMR28 is quite interesting. It's a BCP balsonin. It's also
been known as P97. It's an activator of that molecule, of that protein. Generally, you find
small molecules that are inhibitors, but we actually found this activator, SMR28. And over
the years, over 20 years, many groups have independently verified that SMR28 is a bona fide autophagy booster. It's been shown in worms,
flies, fish, mice, rats. Even in mice, it's shown that SMR28 can cause hair regeneration. So
I'm going to be spending a lot of time posting about the sort of the scientific thesis behind
combining an mTOR-dependent and mTOR-independent combination for boosting autophagy.
And we'd love to dive into the science there.
And we're super excited that Raptor was able to secure funding for worm, fly, and mice studies,
all in less than 24 hours. Amazing. Thank you, Raptor holders.
It really does prove that you can gamble on research, and we can convert crypto animal spirits into longevity data. Pretty amazing contraption
the pump science folks have built here. So very jazzed to be here with fellow devs and can't wait
for this ecosystem to continue to explode. Yeah, and I think what you just said, the
timeframe you mentioned and how fast you were able to secure funding for three different types of experiments is pretty significant as well.
So, I mean, maybe from your perspective, what do you think about this kind of experimentation and the style of experimentation
could reshape early biotech and the space?
Because, I mean, you've been also pretty vocal about the value of of death and biotech and i think this model obviously significantly changed things yeah i'm honestly
blown away obviously it's like there's nothing like doing it yourself you know is watching and
there's doing it yourself and just going through the experience of seeing you know quite honestly
when i launched raptor this week i had no idea what would happen. I just looked at all the other, you know, coins that had launched in the recent cohort and thought, OK, that's the comp.
And then when things started to blow up, I was a little, honestly, pleasantly caught off surprise, but then realized, wow, OK, there's clearly something going on here.
We've got plans here, hopefully, to make this more than just a single asset shot on goal.
hopefully to make this more than just a single asset shot on goal. So I'm very excited to see
how quickly the pump science ecosystem is evolving from a bunch of devs nominating their favorite
nutraceutical to now these combinations emerging. Obviously, the market's very smart. If you see
there's a king of the pill, the likely way to take out that king is to basically team up with them.
out that king is to basically team up with them. You can't beat them, join them is sort
of the philosophy. So we're already seeing that with the other rapamycin coalition coins
that have their own favorite dance partners. So I think that's the ecosystem's evolving
toward more combinations. The chance of a new amount of therapy eclipsing OMI or anybody
or reaching like 50% extension in worms by itself
is going to still be possible.
There's always a two sigma event out there, but it seems less and less likely over time.
So then the best bet is to take the individual monotherapies
that have different mechanisms and then start to combine them,
which the market is doing.
And it's evolving so freaking fast that that's the part that excites me.
Can I say something else?
So the thing that Ethan pushes on is the combinational therapies.
And I think that is a super interesting area,
which also the Replimising Longevity Lab is trying to focus on,
is trying to focus on because a single intervention will most likely not give the biggest longevity effect.
And thanks to Pump Science, we have now a good platform to accelerate the research around combinational therapies,
around combinational therapies, which probably would not have been done
if it was done without this platform.
So big thumbs up from Science.
Yeah, thank you, Matt.
Thank you. So Ethan, one more question I have for you, because also you just started
to mention one of your learnings and that it's interesting to see that it is very much
a communal process, right? Maybe, could you, do you have any other learnings just from
participating in the system, which is kind of crazy if you look at it from the outside, right? Yeah. I mean, I think I kind of hit on this realization last night that, you
know, to succeed in DSI, the science and the scientist have to both be memetic. And if you
don't have that conjunction, then I think that explains a lot of why we haven't seen as much explosive growth
in DeSci as maybe we wanted. But I think that's the key, right? If you can blend the seriousness
and the technical cred with like DGEN speak, and you can kind of in a schizo way, turn on one voice
and turn on the other, it makes the science mimetic, it makes the scientists presenting
the science mimetic. That's what gets attention in the attention economy. And I don't know, I hope others people
will learn that and realize if you don't have any personal riz and all the riz in your science,
that's going to be an issue. And if you have all the riz and your science is crap,
well, we've seen that before, right? We've seen the scams, we've seen the rugs,
but we need to kind of get the nerds. Yeah. I think that's one thing we've learned is it's
definitely from the pump science standpoint, part of the kind of even like the studies and
the end points and how we show it was intended to make it as simple as possible for people to
understand, like looking at longevity studies and really understanding, did this make, you know, worms, flies, mice live longer? Yes or no, was intended
to be as simple and inclusive endpoint. Because a lot of times I think as soon as we start talking
about science, really quickly, you go into a bunch of buzzwords and people kind of tune out.
And so trying to find, to your point, Ethan, exactly the
ways to get people to lean in. A lot of it is through simple, really easy, fun ideas around
the platform, the science, the compounds, the people to get them to understand that there's,
you know, something fun here. And I can, I can vibe with this too. It's not as complicated as
it might seem. Yeah, Julian, maybe now that we're on, and for the people who might be not too
familiar with this, maybe you can just walk us through a life cycle of a compound on pumped up
science. Yeah, for sure. So for people who don't know, pump science was, I guess, like backing way up. So, you know, I think here coming out of COVID and, you know, I think moving into more of like AI and technology, I think we're at a really interesting intersection of a lot of forces coming together.
And people are hungry for transparency.
People are hungry for information.
And people are also really hungry
to make their own decisions. And so a lot of what pump science was born from was really the inability
to answer the question, what is going to make us live longer? And not having a clear, good way to
answer that. A lot of people are absolutely trying to find ways to do that. But as people, as every single one of us, you know, every day that we exist for one day closer to dying, and we want to push that, that endpoint out as far as possible.
So really what Pump Science was designed to do was help answer what compounds can help us live longer and generate the data to do that,
but do it in an open and transparent way. So the way the pump science protocol works is all of the
drug devs that you're hearing from, Ethan and Omipal, what they've done is they've basically
submitted compounds and these compounds become tokens on pump science. And what happens
is, is those tokens, the trading fees of those tokens actually go to funding the research.
So what's been really cool is that, you know, there's, there's three animal models,
these compounds can go through. And again, it's really, it's determined by if there's enough fees
to conduct the studies. First, they start in C. elegans, which's really, it's determined by if there's enough fees to conduct the studies.
First, they start in C. elegans, which is a worm smaller than the size of your eyelash.
Reason being, it's a fast and also relatively inexpensive study that we can do.
Then the compounds move into flies. And then the last animal model is mice. And then hopefully here soon after mice, we can bring humans into the research protocol.
But the way that it's designed, what's really cool about Pump Science is we run the experiments
and we actually show the experiments and the results on our platform.
So for the compounds that have just gone through worm studies, what we did was we
actually took the worm studies themselves and took a 28 day long experiment on average and
actually compressed it into a 15 minute data drop. As we've all talked about, we're in the
attention economy. So we thought that watching worms die over 28 days probably wasn't that engaging. So
how could we take that and actually condense it into a moment? So what we have is our worm fight
club where we, when we have data for the compounds that have enough fees, we stream the science
right in the open on our platform and you can see the results for yourself. So you can see
how the compound is performing, how control is performing, and you can actually see images of the worms.
If there's enough funding, like I mentioned, then they go into flies and we actually show people
the flies flying around in their tubes and then the compounds will go into mice. So what's been
really, really cool is to see how quickly these compounds
have been able to get worm studies funded and underway, and also additional animal models. I
think we have, I want to say we're up to 14 fly studies and two mice studies that have been funded.
So a lot of science we're about ready to be doing on the platform. But as Ethan mentioned, you know, anyone can submit ideas on the platform.
Right now, there is a bit of a DMing our team to get on that, to go through that process.
We're looking to open it up more broadly to people.
But folks who have an idea, just send us a DM on Twitter, in our Telegram, and we will
work with you through that process. But we're really excited to let really people be, we say anyone can be a scientist, and
that's really what the platform was designed to do.
Hey, shout out to Pump Talk Science, man.
I thought that was Benji on a voice changer, but Jillian, you go girl.
We found our mouse study in like 15 minutes with that, but Molecule, I got a question for you, if you don't mind.
Yes, please.
Yes, we launched our P&L, which Cognito is going to tell you about in a few minutes.
We launched it, I think it was two days ago.
15 minutes, we hit our funding goal, and it's not listed on biomarkets.
You have any idea what's up with that?
It's not listed on biomarkets?
No, as far as we know, it's the only token.
Now I'm not trying to, you know, I'm just asking questions.
I don't know if I can give you any answers on what is listed on biomarkets.
Yeah, who we got to talk to about that?
Hey, Paul, where you at, man?
Is he here?
We got to get him in here.
Don't worry.
We should.
I don't think so.
Don't worry, nootropics.
We won't stop till it's figured out.
We got you, fam.
Yeah, for sure, for sure. Hey, thank you, thank you.
Hi, are you guys' P&L on Molecule XYZ, DSI Screener?
I'm looking at biomarkets right now.
Yeah, well, we gotta assume no,
because I'm not trying to say that anybody
trying to hold us back, but we don't see it.
That's all I'm going to say.
No, no, no.
I will investigate.
Thank you so much.
But maybe now is a great time for you as well.
Now would be an excellent time.
Exactly.
Gita, where you at, bro?
Where you at?
Oh, please tell me a mic working, bro.
Oh, here he is. All right.
Can you hear me?
Yes.
So as was mentioning, like we are not topics now.
Well, first of all, thank you to platform and Molecule for hosting us.
But first of all, I'd like to explain a little bit what we have been working on.
And now we launch Pinelon.
Pinelon is basically a nootropic that was discovered in the 70s in Russia.
And for 30 years, or 40 years, it has been really, really deeply used there
and has been many, many effects on cognition.
It has been used for Alzheimer's for neurodegeneration.
And really interestingly is that, apart from having such effects and proven effects on
performance and dementia and increasing like lifespan it hasn't been researched on the west
and we don't know if it has been censored, if it has been for interest, but that also
is something that we find a really unique and a really good opportunity to create research
that only Web3 can have.
Because I know that we like to talk about how with Web3 and with DISA, we can compete
against pharma.
But to be honest, that is really hard.
They have billions and billions of dollars.
They have all the infrastructure.
But we have the community.
The best way to create and to complement what pharma can, or traditional science can have,
is to create from the community through these biohacking communities, taking these
no topics that can have a really real effect on people and a positive effect on people.
Funded and make research through platforms like PAMScien. So I find that this is really promising.
And apart from that, another point really important is this token is the first launch
on Nord Tropic style.
Next, we will launch Nord Tropic style token, that will be the main governance token.
We are also launching the Nexus, that is the knowledge graph that people
that love topics and want to, or neuroscience, that our community is full of neuroscientists,
not neuroscientists, but professional neuroscientists, so people that really love and are really
experts on the topic. And that graphF will be embedded and will be trained
by the community too, so then they can learn about Pinelon
or any other nootropics that they want.
So yeah, I don't know if there are questions or something
or any thoughts?
Maybe I didn't understand properly why you selected the, or how you made the selection of the compounds for cognitive enhancers
compounds for cognitive enhancers to explore in the first place?
to explore in the first place.
Sure, sure. So, we know from the community that these compounds,
these peptides that are bioregulators and that are well discovered by
Kalinsson, has been already tested in Russia.
And there is a really big line of research there
about how they affect biological mechanisms.
They, for example, have been shown to outperform
wild compounds like cortexine and protecting brain cells.
There are also studies that show that it's accelerated recovery from traumatic brain injury,
that doubling learning capacity in a really short amount of time.
It has been to show results on performance, sport performance. been has anti-aging benefits too
um but as i mentioned before a really important part is that most of the research is hasn't been
done on the western traditional science but in mainly for the Russian tradition for almost 30 or 40 years.
What is the Russian tradition?
I mean, Russian tradition is like, because there's kind of a problem in the science,
in the scientific tradition, for example, in the West.
I'm not saying that it's better or not better, but you need to be approved by the FDA if
you are in the USA, and you need to have this classical standard of double blind.
And to be honest, there are really high standards.
But when research doesn't come from those realistic pipelines, then they're harder to
get indexed in journals on one side.
Also, these researchers started,
as far as I know,
as part of like during the Cold War
to protect militaries from stress and toxins.
So it also took like many years to all that research to be open.
And still now a lot of the original research is in Russia.
We also know like original in science, each country wrote their research, published their
research in its own language, even like Albert Einstein, he published it first on German.
It just not currently in the last 20 years, that research or 30 years, that the standard
research is in English.
but still the peptides even that a lot of people thousands of people in the west are using them
there are not much research on it uh there are not much interest on about it. And we don't know, like, of course,
anybody can have its own theories about why that happened,
but we are taking that as an opportunity
that having all the community already,
and a lot of people retaking it, having direct proof.
And apart from that, we can also think about
having decentralized and equal one trials,
that that is something that Web3 can help,
something that with traditional science you cannot have.
And as I mentioned, we really think that competing with
pharma, at least now, is a lost war.
I know that a lot of this is not something that a lot of people want to hear that we love.
I love Web3 decentralization, but we need to build from the ground up from the community,
from the spaces that Web3 can create,
that you cannot create with traditional science
or with pharma.
Hey, May, can I jump in here for a second?
Oh, I'm sorry, I'm sorry.
No, no, no, please go on.
Yeah, can I just say my piece?
Yeah, so basically what he's trying to say,
what he's talking about, Vladimir Cavinson,
is Vladimir Cavinson was a professor in Soviet Russia that was explicitly tasked,
and this is pretty known, not controversial, explicitly tasked with solving the problem
during the Cold War, or given lots of resources to try and solve the problem of regenerating potential injuries to
Russian soldiers if the Cold War went hot. And he ended up discovering a class of compounds that
have now come to be known as bioregulators, of which pinealine is one. And so what Dekognito
was basically saying is a lot of these studies come out of Russia and were locked behind
the Iron Curtain for a while.
That's not hyperbole.
That's just what happened in the story of these peptides.
They're only now making their way to the West.
Nobody quite knows how much to trust the decades of data that the Russians have put out, much
of which is very promising.
And it's nothing specific to do with Russia.
It's just that they, you know,
when you have one country and the military,
you know, with basically a monopoly
on this research for a while, you know,
nobody knows how much to trust it.
And so there are people,
and there are people in the Entropis community
that have been experimenting with these molecules,
taking them there, you
know, as far as we know, actually in the West classified as food supplements in America,
for example, several of the bioregulators. And so they have been reporting promising
results. The human data from the Russian studies over decades has been very promising for all
of the bioregulators, pinealine included,
which he started to get into.
And so now what we're looking to do, as to Jillian's point, is, you know, since pump.science,
you know, is all about supporting open and transparent data gathering, is looking to
put pinealine and these other bioregulators you know under the microscope literally and figuratively
so to speak but anyways um shopkeeper where you at man because we got it we got we got a few things
here we got a few new things that uh decognito didn't mention we also got a kind of a new
economic model um which is probably why our token is uh doing pretty well shopkeeper man where you at
hey hello uh doing pretty well. Shopkeeper, man, where you at? Hey, hello.
I'll say it, man.
Go ahead.
I'll pitch in.
I'm the shopkeeper from the Netherlands.
I have the store
Chemi-X. We sell
research chemicals, mostly some
supplemental, like NMN.
I wanted to speak on the P&L situation because
I heard some debate and even a question from the molecule but the thing is is that there are many
discrepancies many differences between the pharma industry in the Asia and Russia and the vest. So the research and the protocols, the trial pipeline, preclinical and clinical,
they are not a one to one over.
In Russia, panilon is being sold as a supplement,
sold in pharmacies and other stores,
as many other chemicals are.
Nupept, that we also sell,
feniput and other chemicals are sold in Russia like candy.
But in the West, this is a no-go because it has not been done, not rigorous, because the research is very rigorous.
It has not been done the Western way.
Hey, this is why it's being gatecapped in the vest.
This is why it's being gatekept in the West.
But I'm very glad Pump Science comes to help us out with a great opportunity to do the research
and to slowly introduce pan-ilon and other gatecapped chemicals into the vest.
And yeah, we're just here to see really how far it can go because this is a
really interesting product but not only that it is even interesting more interesting project
with pump.science it is the first as i recall a token a crypto token that is backed by an actual
product it is the first uh in pump science history if i uh am allowed to say that when you buy a
product 40 percent of the profit go into the token to pump it this is a true collide of the market the crypto degen sphere
and commerciality and science so not only are we doing the science we are doing the actual product
so you actually try the product that is being sold as candy in russia and we are doing the actual product. So you actually try the product that is being sold as candy in Russia.
And we are getting the science out for everyone to see that this molecule with around 50 years of research is not as scary as some people will have you believe.
as scary as some people will have you believe.
My store itself and the DAO have even a few deals in place with certain therapists in
the US.
They have extremely high clientele and for them it is no problem to take.
But for the common man, it is dangerous.
This cannot be the case.
And I believe in this sense, in the project PNL, that it will be great not only for the product, but also for the interest in the crypto market as a whole.
This is through utility by physicality.
And I think this is, I am regretful,
I heard, I did before I joined,
biomarkets has not listed it on their thing.
This is a little, you know,
hopefully they fix it, you know, rapidly
because, you know, it is going up as it should
fund the science get product and we keep going keep progress this is uh
last thing i wanted to say on ethan perlstein i'm very happy to see you here we have not formally but on the repa my son what's up what's up repa my son i have a question the question the age
age old question uh i had as soon as i uh heard of the raptor products you know mTOR inhibitors
mTOR receptors as a whole are very interesting things you know you eat wasabi, you have the weird sensation on your nose.
This is all because of the mTOR.
My main question is, we have, of course, the one and only Brian Johnson.
He's not here today.
Very sad. But he used the Repa Maison to do longevity, life extension.
He is really one of us amongst the community of self-experimentation,
decentralized trial, really.
He was taking it for long,
but apparently it seems like it is a no-go in longevity for humans.
I think because I forgot some way it metabolizes in humans.
It creates something that's a no-go.
He published some data, I think, not long ago.
This question for Ethan Pershing, how to combat this with anything here really?
I can just go in and say some words here because I have followed. to it. We, the Molecule team pinned the link to the space at the
top of the space. You should see it on your phone.
If everybody could like, retweet,
get as many people in
this space as possible, that's how we'll spread
all the good work that you guys are doing.
Go at it. Go at it.
Yep.
Perfect.
I have followed the thing with Brian Janssen and I have in my profile, you can find some posts where I have evaluated the conclusions that he has done. I'm also self-experimenting with rapamycin and have seen beneficial effects with that.
The thing, as I mentioned in the beginning, when it comes to mTOR inhibition,
many of the longevity interventions that exist today inhibit mTOR in one or the other way.
And if you, for example, use lots of different interventions at the same time, then you can inhibit mTOR too much.
too much. And if you start to inhibit mTOR too much, then you can start to get the bad effects
of mTOR inhibition. So yeah, that is a little bit a rough summary of my view of what happened
with Brian Johnson's self-experiment? I think Johnson himself
that his lifted levels were a little too high.
And obviously he's trying everything at the same time.
So it's an N of one for the ages,
but it's also obviously,
how can you extrapolate from his decision-making?
He has unique genetics as well.
So I think the bigger story for me
is he discontinued because of these questions.
And there are liabilities to too much antor inhibition.
So maybe that's the whole point of wanting to do Raptor and a combination where you could
lower the dose of rapamycin.
You don't have to max out rapamycin.
If you can lower that and get a sidekick to help out, and then that would allow
you to hopefully have more tolerable lifelong dosing. So I'm not saying that Johnson's discontinuation
of rapamycin proves that you need to have combinations, but obviously there's a sweet
spot to our inhibition. And so there are liabilities of rapamycin that we don't want,
and maybe these enhancers of rapamycin don't have those liabilities. So if you use them, you can, you can get by with less rapamycin. That's the
theory. So I would love to have Brian Johnson speculate more as to why rapamycin monotherapy,
I mean, he wasn't doing rapamycin monotherapy, he's doing polytherapy and rapamycin is just one
of many variables. So I wouldn't conclude from his discontinuation, you know, I wouldn't over
interpret it, but, but yes, I do think it speaks to this point
of rapamycin's not perfect
as much as I've been worshipping rapamycin
for all my adult life.
There are aspects of it
that can still be optimized.
No, okay.
No, I understand.
It was just a small question
regarding the, yeah, it sounds good.
I'm very happy to, maybe we will see from the experiment, you know, what is going on, maybe, or, you know,
Pinilon itself has been in the Russia literature, of course, 2,000 times at therapeutic dose, 2,000 times therapeutic dose, still safe in humans.
So it's looking really good. You know, it's just a different cake. But of course, for such rapamycin, I understand more experiments needs to be done to really see when the benefits start
and then they end. i totally understand we have community
constant self-experimenting uh some for uh ailments defined ailments such as
uh um cancer or other ailments and you know when the doctors say you are done you are done
And, you know, when the doctors say you are done, you are done.
But the human will is strong.
So, you know, they will search for other alternatives, look and see.
And the open pump science, we can differentiate between the working chemicals and the non-working chemicals.
and the non-working chemicals.
To look for example,
a while back we had the ivermectin,
corona or the other things
that might be effectful
but might not be at all
what people think they are.
And I think with pump science,
they can really show effectively to the public
that in general,
this will be to biological organisms a no go. So small, small chance that it will work for this, this or that. But yes, this will be very interesting.
ever the evero limus also interesting uh yeah m tour as well so this is also very interesting uh
regarding this because i i heard less side effects in general than repa my song because i know a few
self-experimenters that have taken it uh yes it is uh well this goes more into the risky
And yes, it is, well, this goes more into the risky self-experimentation, but from what
I know from this person, more socialization, but, you know, side effects are side effects.
There are some there, but Evero, Milisot, Limus, sorry, my English is not what it should
be, but it looked good as well. Looked very good. So I hope pump science can bring the truth up
and also numbers.
This is very interesting, very good.
Regardless, good to meet both of you.
We have not met.
We have not met, so good to meet both of you.
Thanks for joining.
I do know too, it looks like there's a few drug devs out there that want to speak.
Mirio, if you're out there, request the mic.
We'll get you up here.
And also we have-
Psydow. Psydow's in there.
Psydow's here too.
Oh man, got the whole fam.
Okay, we'll do Mirio and then we'll do the drug dev with Gingy 2, Ging 1, and Beast.
You can request to speak.
We'll bring you. Yeah, man.
Yeah, thank you for the time.
We ain't trying to take over the spaces.
We just, you know, try to take over the spaces a little bit.
But we appreciate it.
I hope you stick around and vibe with us.
We'll give some of the folks to the floor, but don't leave.
All right, thank you.
All right, Mirio mirio you out there
let's get you right betmacourt's in the crowd too d sign maxi yo i i gave him i i requested for him
to speak earlier but i don't know if i can do it again ryan you're always welcome always welcome
always welcome
alana do you see the uh request to speak let's see yeah i'm just approving cool cool
they got to get their four scramblers ready i forgot mine you know what now i'm like yes yes
it's on your you're not you're not crypto enough every crypto expert has
the the either the high pitch or the low otherwise it's not crypto enough i love it deep throat
we got squeak throat here how you going squeak throat squeak throat where you at mario we love
mario we've been buying that up we've been buying that up where's mario at
We've been buying that up.
Where's Mario at?
They gone?
They ghosted?
I don't think so.
I think they're trying.
Okay, let's see.
Drug dev for Ging2, Ging1, and Beast.
You request to speak?
Let's see.
Let's find him.
Hi, everyone.
Can you hear me?
Oh, yeah.
Loud and clear.
Great.
So my name is Ashish Rajput.
I am based in Germany. I am a scientist by profession.
And I am the drug dev for three compounds actually, so I can pitch them one by one.
First one is called ginseng RH2. First of all, I have chosen this compound because I wanted to
connect like our ancient knowledge with modern research.
So all these compounds are coming from ginseng.
Ginseng, as you know, is like 2000 year old medicine.
It's used like in Chinese, Japanese, Korean, and this kind of Asian as anti-aging therapy.
And these compounds are derivative of ginseng so we know these are safe for human consumption this is like very important for me so once we go for like trials
in mouse and at the end for human trials they will not cause any problem uh yeah as as we can see so how they works the ginseng side rs2 we
can in a simple term we can think it as a guardian of the cell so it fight oxidative stress it fight
inflammation mitochondrial decline and cells and since these are like very bad and come with the aging in molecular level
it activates nrf2 pathway it is known as a master regulator of cell antioxidant enzymes and all of
this sod catalase ho1 these are downstream from these enzymes. So it really works on the upstream of all this cellular protection pathway.
It also delays senescence by modulating p53, p16 pathway.
You might have heard these with senescence and all the anti-aging research, cancer-related pathways and so on.
So this molecule, ginsengcide RH2 or in token form we are
calling it GINH2. It is directly activating these pathways and protecting our cell from getting
aged. The second compound and also before we move to second it is already tested on worms and it is
showing around 28 percent life extension in worms. So that is really nice. It is safe and it is showing around 28 percent life extension in worms so that is really
nice it is safe and it is also showing pretty good amount of life extension the second one is
ginsenocyte rg1 it is working as a rejuvenator so it protects like it boosts our brain function, it boosts our stem cell vitality, kilomeres.
It has not shown very much life extension in worms because it acts like a long living organism.
So I'm hopeful it will work more on flies, mice, and I mean, as humans are like quite long living so it should work on work on us actually.
How it works it's again activating PI3K or AKT pathway it also works on NRF2.
Basically it increased the neuroprotection stem cell renewal antioxid defense, and so on. So somehow, if you see like PNL is somehow similar in this sense,
it is also activating BDNF and protecting our neuronal cells.
So yeah, I would also maybe check later on
if it can integrate with PNL and similar pathways.
The third compound is called BEAST.
The name is coming from its component.
BEAST is coming from broccoli because the component it has, it's called sulfofilene.
This also activates the NRF2 pathway.
It is the master regulator for antioxidant, as I said.
It is inhibiting our anti-inflammation, protecting mitochondria, epigenetic rejuvenation and so on.
And the uridine, most of you from the biology background, you know, it is a pyrimidine nucleoside.
It is part of our RNA.
Like we start from DNA to convert to RNA, then go to protein.
And RNA is very much important for all of this process.
And it is one of the main molecules which
prepare the RNA. So overall when we give it in more amount as a supplement it protects
our mitochondria, neuroprotection and also sleep and circadian rhythm. So I'm very hopeful
it will also give like it can become as a longevity supplement for humans.
It already showed around 24% life extension in worms.
So I'm looking forward for the flies and mice experiments.
Yeah, over to you.
Thank you so much. I see we have Mirio as well now. So if you want to speak up about
your project now at the time, yes.
Are you here?
One second. Are you here?
One second. He's trying.
Let's see.
Yeah, I requested.
I approved the request already two times now.
Yeah, they might have to jump out of the room and come back.
Ryan had that issue.
I think he's now on stage.
Yeah, I had the exact same issue. I was trying to accept uh the invite just couldn't
it just didn't work so i had to i actually had to close my x app and then restart the x app just
just in case anyone's listening they can't come up oh i'm sorry oh no no no probably it was it was i
think it was an x problem this is on elon This is on Elon. Yeah, this is on Elon.
We should send it to the Elon customer complaints office.
We should.
Yeah.
Hopefully we get a nice meme back.
I just wanted to kind of share how exciting everything is at the moment as a, I guess,
as a DSiMaxi, just seeing, you know, everyone bringing, you know, combinations,
novel molecules, and having a affordable, accessible, decentralized way of testing these
as well.
And so, you know, I don't know where everything is going.
Obviously, I love a bunch of them, including Raptor, which, you know, obviously, Ethan
is an incredible entrepreneur,
biotech entrepreneur and investor himself.
But I think that just the-
Shout out Ryan to you.
Ryan is the one who generated the Raptor logo
and the Raptor name.
I did.
Ethan and I were riffing and I was like,
you know, it has to have a great name.
And that's where Raptor came from.
So it was a combo of me, Ethan, and a few AIs,
Grok and ChatGPT5.
So really fun and really excited to see where all of it goes.
So, you know-
Is there anything you guys can't do?
Logo design?
Startup?
I mean, it's crazy. It's crazy. Well, by the way, one of the things that I learned,
so with, so Wild Earth, the company I just exited, so I built a CPG company called Wild Earth. We're
still the leading plant-based pet food company. Long story, but eventually we got acquired.
And by the time we got acquired, we had a total of five people on the team and we were doing about 10 million in revenue.
And so, you know, roughly about about 100,000 roughly in in in monthly profit.
And and the way we did that was by making a really streamlined team where we really relied very heavily on A.I.
team where we really relied very heavily on AI. So we would do a lot of the work that we had to
do with our team and harness AI with it. So it was like a really qualified high agency team member
plus AI. And that collapsed our costs at our peak. We had a total of 35 full-time team members
and we collapsed that to five.
This is the only way to build.
And I think, you know, the fact that you have so many solo devs building, I'm sure they're
augmented with AI too.
I mean, it's just going to get better and better.
So all y'all, if you want to get your project to take off, you've got to be mimetic.
You've got to speak DJ-ness.
You've got to look the talk.
You've got gotta walk the
walk but uh I think everyone can pull it off yeah and I was just gonna as I think we all have
to hear me yeah oh perfect at least I I have some technical issues because I was also with
Mirio chin account and also with the dev account my account sorry for being
such late but yeah go on i will be i'll be when whenever it's my turn
technical issues are done so yeah But take the mic, Valentin, and present yourself.
So I'm the dev behind the mediocrine and alpha-ghetto-lutarate I choose those two compounds because one of them it's they they
they do different stuff and if I can talk first about the Mirio chin Mirio chin it's one of the strongest known lifespan extending compounds in c elegans particularly
in c elegans by inhibiting the spingolipids synthesis it's reducing toxic accumulation
inside the c elegans and activates stress resistance pathway and also boost autophagy
keep the cell cleaner it's like a cleaner and it's a fungus it's a mushroom from japan and asia and
the main purpose uh was to find find a compound that do well with this elegance in the first place
because we are not building only just one compound or we try to build the beginning of something
much much greater all of us around here and I do support any any compound that it's here because
they are activating different pathway and also they work differently inside every organism and we have to
test them all and thank you for pump science in the name of all that they give give us the
the opportunity to test them and move further yeah because without the test you you you do not know uh in which direction you should
go like uh yeah uh regarding the the project in Miriocin and Alpagetoglutarate we are only the
beginning uh we see we are super angered to see the results because we are super bullish.
There are some tests that claim 100% increase in lifespan in C.Elegance.
I know the guys that are in PhD in medicine and the experts in science around here knows
on in medicine and the experts and science around here knows that i'm aware that myriocene it's
it's it's toxic for a human body but in in immune time uh there is a an extraction from the myriocene
and it's an fca approved uh it calls fingoli mode I do not know if I pronounce it well in English I know
it in Romania because it's also present in my country and you can buy it if you have MS
like multiple sclerosis and show some good good improvement in this kind of disease
good improvement in this kind of disease.
Yeah, super happy to be here.
I got some emotion and yeah, excited about it.
But yeah, thank you for having me.
I'm here to build and the next step will bring us the next step for
Miriocin and alpha-getoglutarate project
that it's a wider and bigger project
will come next week
so we will prepare
something super nice for our community
and not only for our community
for all the pump science
builders
and believers
together we are strong
as a community
all of us
working in the same direction
to improve
and to see
to achieve that feel
that can bring
oh it's so silent
like it's super silent
does anyone hear me?
yes we can hear you okay it was extra super silence. Does anyone hear me? Yes, we can hear you.
Okay, it was extra super silence until I speak.
Beautiful speech.
Yeah, I got some track, you know.
But yeah, it was better next time maybe we can see each other.
Because in front of the laptop, it will be only a monologue.
I love people.
I love people.
I love everything what you've done, all of you.
Raptor, P&L.
Of course, I feel that I'm not a scientist.
I'm not a scientist. I'm not a scientist. I got a PhD in finance and in IT, but for sure, this field needs also other experts that can have better, like super, super anger and grit, full of grit in order to research and help with ideas outside of the box.
It's super important sometimes when you get the challenge or a thesis,
you have to see also from outside the box because new ideas are coming from other spaces and other domains.
I'm that kind of builder and what I plan to do, it's way bigger.
And I'm 100% to bring it to life.
And it will be live next week.
We aim for the next week.
I hope I will not delay it because I don't like delays.
I will be there.
Thank you very much.
Thank you so much.
I think what you said is really important because, yeah,
it is a place of experimentation of bringing people together
from all kinds of research backgrounds.
And yeah, where everyone has the opportunity to participate in science really
um i think there's also another deaf from another compound who would like to speak up it's a bpc 157
I see them trying, but I don't know that it's coming through.
I'm here. Can I speak?
Yes.
Oh, wait.
Welcome.
Thank you. Thank you. Sorry. I was having some trouble with also the spaces.
Always happens this.
Well, my actual name is Eric Zamora.
I'm also known as Crypto Reumd.
I'm a medical doctor, as all you know.
And I'm very excited because I was hearing everything that also my partners said about mTOR.
I'm actually using cyclosporine and tacrolimus to control my autoimmune patients,
and also I use fingolimod in some patients with multiple sclerosis. So yes, I'm actually aware
of these drugs that actually are helping me to achieve the control of my patients.
I'm really interested in everything that we are building here. I also joined the
PhD from Pumpto Science since December, maybe November of the last year. And I've started to
realize that they are doing something great here in the DSAI space because they are actually funding projects.
I think they are doing real science as molecule and as bio
that actually are like working a lot.
But we try now to make our project something also different.
We need to make something like a basket of tokens of the other projects
to help us grow and also make boybacks from carrots
to also keep funding the next experiment.
Because we modified the dose.
We are using quercetin and berberine.
We raised a little the dose of quercetin and I love the dose of berberine since we noticed
that the results didn't go well in the first world study.
So I'm really convinced that everything that we're doing is going to be great.
Even if the project doesn't go to the king of the pill,
we're going to continue here trying to help the other projects to get them visibility,
making some fun videos, memetic-like experiences.
But I have a lot of ideas,
so also we are going to be funding other projects
by the KERS team.
So thank you, Gillian.
Thank you all the POMP.Science team,
Molecule team, to allow me to speak and to keep building.
Super cool. Thank you so much for giving such a nice explanation of your project as well.
I think there's one dev we're still missing is AKG.
I think there's one dev we're still missing is AKG.
I'm the dev from AKG, the Miriochin, Valentin.
Oh, I'm so sorry. I'm so sorry.
Don't worry. I can story about it,
but also the main purpose of the first two compounds,
as I tell you, Miriochin, it's the one that I aim to be the king of the first two compounds as i tell you a meteorchin it's the the one that i aim to be the
king of the pill in in c elegans because i'm aware that meteorchin does not do any super wow improvement
that flies or human it's too toxic you consume it because it comes from a mushroom that it's toxic for our body.
But as I tell you, for flies and mice and human, I choose alpha-getoglutarate because it's the optimizer of the human body and optimized energy.
And all my research in this field show super wow improvement
and in future for sure we will have a pill that will stop us from aging and dying as much as
possible. I'm 100% that that pill will have a small or a bigger one concentration of alpha ghettoglutarate I'm
I'm super confident in that and the next project it's the the base of the our next projects the
foundation it's side by side Miriochin and alpha ghettoglutarate for sure they will be forever our base for development
new compounds are coming for sure in in this in this project can you can you hear me yeah
we hear you all right thank you that's good i've been trained for hours and this is a shame
on elon musk i'll be very quick because i want to leave space to others as well so i'm very excited
i'm the developer of bpc 1.7 which is a compound that i've also been using myself and as it was
said previously there's a pet which starts on c elegans and then there's flies and then there's a pet which starts on C elegance, and then there's flies, and then
there's mice, and ultimately humans. And with BPC-157, we already have promising data from
humans, but when we were producing data on C elegance, that was the first time ever that
such data was produced. So there was no data before. We produced data that didn't exist.
And this is so this is exactly what I'm what I'm here to do as a scientist as a live traditional
science because I wanted to perform data to produce research that was not done before. So
that's the main reason why I'm here. And that's why it was natural for me to join
PAMDOS Science and to explore these compounds
so that we can produce data that is missing and I'm also very grateful to Molecule for featuring
oral compounds on their page and I just have a question if they will allow us to also put the
official links to the website and to amend the official information to make the page look even more
more information even more official so you mean the molecule page the screener yes yes if you can
add the official as now it says the information if you can add like the link to the official website
the official Twitter for each for each compound so yes. We're actually currently in the process
of redesigning the interface.
Right.
Perfect, perfect.
Thank you very much.
And maybe for everyone who doesn't know,
you can track all tokenized science IP on our screener
across Solana, Base, and Ethereum.
And all the experiment data from all the POMP.Science experiments
will be streamed into Molecule Labs, which
is like the project's GitHub interface,
where all data can get published and posted.
And it gives everyone an interaction point.
So the science is open and accessible to everyone.
Yes.
If the possibility for the P&L is possible to be also listed, this would be very good.
I will investigate this.
Yes, yes. Investigate so we can investigate the PNL in effect.
Exactly.
Exactly.
Yes, this would be very good.
BPC 157.
Also interesting.
Our store itself is going to sell it soon.
Very interesting literature on this as well regarding tissue regeneration and injury recovery. I know some self experimenters that have,
of course, I must say, I do not condone this legally, but now legal talk is out of the way.
Now we can speak.
He injected it into one of his parents
one of his parents because there was a knee oh i hear a car car noise there was a knee injury
because there was a knee.
that did not quite go away after a month of therapy and other experimenting with supplements
you know every time old person is suffering from cartilage they give the standard
mix but at sometimes it is not good enough after injecting it by the knee it was like
lifting 20 kilogram off the back it worked and it was permanent. From literature I've seen, it is not quite the solution for permanent chronic taking.
But it has its use case, especially when there's an injury present for fast recovery.
recovery and this is also where it is used in the bodybuilder scene as an
alternative to the other compounds let's say but it is quite interesting I've
seen people that have suffered from how do you call this not malnutrition but
the inability to eat as much BPC can really boost the number here of how many,
maybe if you are American, Big Macs, you can eat.
So it's quite interesting to how the community
is looking for solutions to what is not considered classically an illness or ailment,
but still a problem. Same as Nootropics DAO, formerly intelligence or lack thereof,
is not considered a ailment of sorts or something to be solved more something you are just born
with you are either born stupid normal or intelligent but they take it upon
themselves to put it as a mission that it is actually a problem just like death
is a problem and we need to solve it and we need to do this quick
and even marginal improvements improving intelligence globally by even one percent
will increase our speed of solving all other problems if If we have 10% better people, smarter people, then we can solve problems faster. And iteration, even with a few percent, can really mean a lot long term for our race and species. we cannot yet uh measured intelligence on worms as i have understood from pump science but uh as
as always we will find the solution and with red is it is somewhat possible but we will find the
solution iterate quickly and hopefully uh we will all be smart at some point. Yes, but it's very interesting project, BPEC-157.
I wonder what it will be like,
Chronic taking it for the worms.
Very interesting.
Yeah, thank you very much.
And one aspect which is very important
is that, as you mentioned,
usually we have
data from the compound taken with injections as bodybuilders may be used to
these but common people are not used to making injections so a very important
point is that we want to produce data on oral effects so is it effective taken
orally because that's what most people would take. They will take caps. So we want to produce data on that because right now,
what the effective dosage if I want to take BPC-157
and I buy caps where it's available,
what's the optimal dosage?
Will it have an effect taken orally?
We need to produce this data because that's like the most common road
of administration to making it available for most of the people. So that's like the most common road of administration for to making to make it
available for most of the people so that's very important data to produce the thing that is is
that uh orally top of my head uh bpc is i think uh 15 amino acids uh long This is pretty much impossible to orally absorb in a human. This is not possible.
The peptide transporter in the gut in the small intestine will not take this. It will be broken
down into smaller peptides, into four lung, three lung, two lung two long maybe one and it will be an amino acid and then it
will be uh consumed but uh 15 long orally i think there is small evidence it does something for
gastro uh stuff but it is pretty much uh it's pretty much either inject muco like in the mouth nasal maybe I've not heard
of it but orally it is it is you will not get the BBC it will be broken down
into smaller components and have been absorbed well actually human actually
there's the egg form and there's some like compound which was claimed to be
orally available.
So we also want to investigate this.
There was some company which created an equivalent which claimed to be orally bioavailable.
So we want to investigate this as there's people taking it orally and reporting benefits,
even just not just for the healing of the gastrointestinal tract,
but also for general healing as well.
So we want to investigate this to produce data
because this is exactly what we need to have,
official data, which is not available now.
Yes, it is interesting then,
and I think any person that understands peptides will tell you
that a human cannot absorb orally in like in general peptides longer than four.
It has been studied. It is pretty much it's it's not something that is possible for humans to absorb 15 peptide long orally in general.
15-peptide long orally in general it is not really a thing I know because my store chemiax has
developed oral peptides we have pineal on orally we have violon orally the surgeon orally um you know i've produced them with um doctors and pharmacists we have checked
blood concentration it is uh we've we have seen the studies it for 15 long it is practically
impossible the villain we have or we have seen it is orally available. It upregulates, it is seen, you know, by, it is a crazy number, but 700% inhuman by the data.
It does all sorts of things, longevity. possible to orally take long peptides, 15 long, 32 long. We would all be orderly swallowing insulin,
human growth hormone, HMG, and others, but it is not possible. This is why they all take it
is not possible this is why they all take it um injection and you know there's even a limit to
trans muco to the absorption in the mouth but um it is not uh it is not real to do this orderly
for example the villain we have it upregulate irisene this is essential to longevity it is
It upregulates ilicine.
This is essential to longevity.
It is, in that sense, for longevity, better than BBC and orally available
because BBC is impossible.
15 long is practically not a thing.
But we are always interested in developing peptide products, intranasal, any mechanism.
But BBC is pretty much right off the bat, is impossible
to do by just, yeah, we know this from long history, like above four, it is practically
impossible, less than 1% chance.
it will be broken down. So that company, I hope you're not...
It will be broken down.
you maybe misread claims or claims have been made that is...
maybe that is why they have disappeared, but it is not...
Yes. Yeah, that's what we are here to investigate. Yes, as I mentioned, there is a
company called Syntagen which claims that they created a more stable form of the regular BPC-WAPF7,
and that by reducing it to a form of an analogue, it is resistant in its rough form to digestive enzymes and degrading agents.
Therefore, it is suitable to use it in capsule form.
So as there are those claims, making it about the fact that it is in fact possible to the oral administration.
That's exactly what we need to investigate.
Are those claims real or not?
That's why we are here to investigate.
I can talk from personal experience saying that I've been taking it in oral form
and, you know, just from my personal experience,
I can say that there is an effect, but this counts nothing,
as we need to produce hard science, and our science is based on data, which is exactly why
we need to produce official data. You've taken orally BPC, 157. Yes, yes, for more than a year,
actually. Then it must have been, this is not to be rude it it must be placebo because the
company you are speaking on there are some ways to make um peptides into there's many advanced
ways that cost a lot of monies it's in in some cases it's not worth it to transform a peptide i think it's called micronized uh or nano particles uh sometimes
there is a way where there is a will but in general if you are taking bpc157 orally i'm not
sure what the benefit is you're getting it must not be you're not getting bbc157 it is broken down
getting BBC 157. It is broken down into four other peptides, five other peptides. It is
biochemistically impossible. You can look it up, what the humans does with a peptide that is 15
long in the stomach. It might not even survive the acid there, depending on the peptides.
Yeah, that's what we need to establish. If the erg form makes it more stable and so it therefore survives the acid environment.
So we need to perform specific studies.
And this will be very useful to establish exactly if the oral roto administration can have an effect.
So there's reporting from data saying that from people taking it, saying that it does have an effect, but we need to establish if it's placebo or not.
So even if I had personal experience, I cannot say that it is effective or not because that's not our science.
So that's why I'm here and I'm very excited that we have the opportunity to establish this because if it were through the traditional academic grants, it would take years just to have the application
approved but on time well it would be it would be denied it would be denied because just add one
thing to this bpc conversation is that uh when it's even if it's not going to survive uh and
maintain maintain its stability because of how long it is.
When, if it's cleaved into multiple sub-peptides
that might have activity in connective tissue,
that could be one way that it works,
even if it's not orally bioboblable.
But Vilon is in the same class as pineal lawn and and that is the peptide that
upregulates space like iris and expression by 700 percent and this is uh irisin obviously is
is a signal for tissue repair it's if vylon is violent has almost 100% oral bioavailability.
So Vilon is essentially a better BPC.
It also has less side effects.
BPC has side effects at high doses.
Vilon, just like vinyl, is extremely safe at up to many thousands of times therapeutic dosage.
We've seen it greatly accelerate wound healing
and burn healing in severe burn victims, for example.
Anyway, that's all I wanted to say.
Yes.
Good to see.
Thank you for interjection.
But what you're saying is correct.
It will be lung peptides like BPC-157.
It will be broken down into peptides no longer than four.
So the BPC is 15 long, I think.
It will be broken down at least four times,
at least into smaller peptides.
But you're getting then a bunch of random peptides,
a bunch of random amino acids.
This is now very hard to study for human.
And also you're getting it in very small doses so I have no
of course it is possible for you to swallow the PPC 157 but the effect you are getting is
not from the 157 for it is absolutely destroyed by your body every if you were to apply for a grant it would be instantly denied because
they will tell you this will not survive uh this will not be absorbed orally you must make it
into a better form you must uh i don't know nano technology okay you must use uh a very sci-fi
things to even absorb it orally it is a tough world out there in the gut for a peptide longer than four or
three.
So it is quite the battle.
But yes,
maybe it is your BPC 157 has been broken down effectively to peptides like
Vylon,
Pinolon,
Vasugin.
These are four, three peptides like vylon, pinolone, vasogen, these are four, three peptides.
High chance it has been broken down into one of these,
and then you have felt some orally effect,
which can be felt at doses as low as 100 micrograms.
So it must be that, but orally, you're not experiencing 157, unfortunately.
It must be more work- BBC might also, it's actually an amazing peptide,
but you might find it does have an effect at 5-H2A receptors in the brain,
which basically has a blunting effect.
So it can lead to things like anhedonia, basically, the opposite of the opposite of motivation and and attentional vigilance.
So it can lead to things like anhedonia, basically,
So it's another thing to watch out for if you're taking it long term.
Yes. It has neurological effects as well. And they're difficult to reverse.
Yeah, maybe. Yeah. I've heard anecdotes and adonia for this particular compound, but for healing rate, for healing tissue, and in short bursts of taking it, it has shown, at least from what I've seen, potential very, very good. But for longevity or we, of course, will see because the humans studies, the human data will not one to one be elegant.
This is a fact, but we will see what it will do in elegance.
Maybe they metabolize it differently and they, you know, they will do something crazy with it.
And then they will not be depressed
they will not have an adonia who knows but very excited to see i mean uh but yes regarding oral
it will be broken down into other other smaller peptides uh well there's also mouse data from
experiments uh taking bpc157 uh from drinking water. So we can also analyze the existing data, but
there's definitely data about... Yes, correct. But the peptide transporters in the human gut
are not those of the mice or rats. But the human gut, you can look it up, the peptide transporters
will break down a peptide that is longer than four.
I think that actually BPC, Wolfbox 7, does maintain its integrity.
It will be broken down some, but I think it does survive gastric acid.
It is derived from gastric juices, I believe.
But yeah, especially for the gut local activity for GI issues.
Yeah, that's why we need to test different forms like the salt arginate form
to see if it's more resistant to the to the gastrointestinal
tract or other force that's why we may be able to create like a more stable form
so hopefully maybe we'll get to the point to perform this kind of research
yeah yeah this is possible yeah maybe we can collaborate Maybe I get some BPC I have here and put it into other form and, you know, experiment and see the blood concentration that is actually there.
You know, maybe it does have some effect without going into there, the blood.
But, you know, that is one way to measure.
But, yes, interesting regardless.
Sorry for the, maybe boring for other side notes.
It is very specific maybe.
I'm also opinionated by the data I've seen.
So of course it's best to see it,
see it in reality and do some experiments.
Your input was extremely precious and well appreciated.
Thank you so much for the discussion.
Okay, yeah, no problem at all.
I'm always here.
If you would like to collaborate,
maybe once you have the data,
turn it into capsules.
We are always there.
Our peptides are custom encapsulated
by one of the biggest nutraceutical firm here.
We work with the pharmacies and get it done.
So BPC, even though it is a little bit on the risk ear
part, we would still be happy to make it available for experimenters,
for our lab rats out there, maybe is a better word.
So this will be interesting regardless.
Let's go.
And I think you guys, like, just as someone was watching the,
I guess, listening to the conversation, you know, like,
it was so cool to see the collaboration of, like, fodder on ideas and coming around to different things to test or different ways.
And honestly, that's exactly, it's so cool to see you guys doing that in real time because that's exactly what we love about this community is the building and compounding of ideas and finding different ways.
And honestly, like, this is how we'll get to that pill that'll help us all live forever.
So I appreciate you guys doing that out in the open.
It was really cool to see the whole exercise.
And honestly, you guys are, I'm just blown away by the intelligence of this community.
It's so freaking cool.
Yes, well, let's get the uh intelligence up yes yes let's uh let's get the intelligence
more up and then uh we create more stuff and uh it is very interesting i'm most interesting to
be at uh i myself am not the crypto uh i'm the crypto newbie, I guess, but it is interesting to see the interjection between product and logistics as I do that.
where the funding of creating this and that product can really be helping in some sense
people all over the world this will be this will be great mark advice for the crypto where you get
where selling the product is fueling also the crypto graph, this is absolutely, it's perfect, you know.
So even if you're not into crypto, you buy the Panilon from the Helio link,
almost half of the profit go into the crypto.
And if you're only interested in the graph, go up from the crypto,
all you need to do is market the product it just goes it is symmetrical
identity really one helps the other and the other helps the other as well it is uh it is good and
i'm happy to be in the intersection of creating the crypto tokens uh to reality because the crypto token is good it is nice to have the experiment as pump science does
supply us but after the experiments are all done and we keep of course keep experimenting keep
pushing the boundary we will also push it in reality as the Panilon does for example, but we hope to do this
and collaborate with others
for vitamins
we have some vitamin coming out
and other supplements and other
products as well, this is really
where I see the
crypto collaboration
here with the pump science
going all the way up
crypto up and product up.
You know, it is good for all.
But yes, maybe I speak too much.
No, I think also what Julian said,
it was super valuable to see.
And I think it's also, yeah, one of the core ideas to experiment,
to bring the community together. And I think one of the things a lot of you guys mentioned is that
there's, yeah, just a little bit of a divide between industry interests and community interests,
maybe. So it's nice to see the community come together and want to create and want to put out
good science and good research and also to
make clear that there is an end goal to all of this and this is to find find cures find medicines
and yeah make us all live longer better lives healthier lives so this was super super interesting
thank you so much for all of your input guys and for joining this conversation um if anyone wants to speak on
anything else this is your time to shine i guess uh yes uh it was interesting i've spoken too much
but i will end uh it will it was interesting to uh be here i'm i'm new to the crypto but it was very interesting um honestly i'm from the modern
because i i can i can understand i mean the space seems quite intimidating from the outside
you know especially if you're if you're new to crypto and then there's this side which is a whole
different part of it right yes so to get through all of the layers and everything
yes so to get through all of the layers and everything well I have nootropics
dow to and pump signs to guide but if not for them it is it is more difficult as
long as we don't speak into a very cryptic crypto stuff then I'm lost but
I wanted to say nootropics dow is here all drug devs are here. And for me, it is a non-competitor website.
Kamiax.com.
It is there for products.
I had also a smart shop, which is a Dutch word.
Technically, it is not known amongst the Americans.
But we were to sell.
The website will be up soon again.
We were selling psychedelics and other products legal in the Netherlands,
made possible to everyone.
And Herbiox, which is for the supplement branch, very good.
It will also be up soon.
We wanted to shout out.
You guys, we just had a wait.
The man, the myth, the legend just joined us.
Want to give him some room to chat yo are you guys still going we're vibing man this community is lit dude i feel like i feel
like we should all be going and doing science but you know i'm here for it. There was just a public riff on like an experiment, which was really cool.
Sick.
Where?
Yeah, I guess what's coming next, guys?
Like, where are we going from here?
The science is pumping.
A ton of science to do.
Where are we going to take it
nootropics now however have you guys got any sales from the helio link
there's a shopkeeper would have to speak on that um but gotcha. There's another thing. We will be announcing.
I think we announced through the space that all PNL holders will receive NDT airdrop
for the Nutri-Mapixel official token.
Additionally, the NDT airdrop isn't just it.
If you're a P&L holder, you will also receive continuous passive revenue in the form of NTT once the P&L studies complete because the NTT intelligence protocol, the Nexus, rewards contributors and knowledge workers.
protocol the nexus rewards contributors based uh and knowledge workers so uh pnl essentially
uh yeah there's a lot of ndt benefits for the airdrop and the passive rewards that's
something we haven't announced yet sick amazing well maybe some of you guys aren't privy to that
we're just cranking on in the background is uh're talking to Dick Dow. So they want to test
a bunch of different supplements and drugs to see how hard they can make the mouse's cocks.
So, you know, that's kind of their endpoint. It's obviously like slightly less longevity focused
and slightly more like male health, but that should be a lot of fun on just like, yeah,
erection hardness as kind of like the end point which will be
hilarious and like sexual behavior so um we've wanted to do like a sexual behavior assay um
where basically you take a mouse and you put it and you give it two options basically same sex
or opposite sex and you see like where it goes um and so yeah it should be a lot of fun a sexual behavior
ass a would be
ass a oh that's a good one I was honestly
thinking of like calling it so
I mean if you think about it as a game show like what would you call
this game show and I was thinking of calling it
are you gay
anyway
so yeah that's cooking We're working with a brand, a wellness brand,
they have a homeopathic medicine that is a combination of three different toxins.
And funnily enough, it actually lowers your inflammation. But and they want to run a human study. So we may get our first human
study, um, like team that wants to launch in humans, um, locked down this week. And maybe
just to tease you guys here, cause you're all, I mean, you guys have been here for how many hours,
like you guys deserve the alpha at this point. Um, it is a combination of bee venom, like honey bee venom, blue scorpion venom, and then poison ivy.
So that's their cocktail, and it lowers inflammation, it improves sleep, it lowers stress.
It's actually insane, but it's obviously like really low dose.
How did they find out about that?
I have no idea.
I actually have no idea.
Homeopathy regularly.
It's very specific.
Yeah.
Homeopathy dilutes it to the point where there's no actual compound in the final medicine.
The idea is that the presence after dilution, the presence of the so-called energetic signature
of the compound remains in the sugar in which it's suspended.
Personally, I think homeopathy
doesn't work at all.
So this study can certainly help.
That's the cool part.
We're going to run the study
and we're going to freaking find out.
They've been on Joe Rogan.
They've been on Joe Rogan.
They had the liver king shilling them.
Clearly there's something going on like they
kind of retarded though exactly so yeah i'm a bit concerned about that too like is that actually a
bull signal like for attention yes for you know effectiveness absolutely not um but they have like
you know i think a solid contingent of ufc fighters that are on the venom they call it the venom like
oh yeah that guy we got him on the venom it's kind of okay looking forward to seeing the study yeah
it's also highly memetic because like i mean literally they have a scorpion farm in the
dominican republic um and they're just farming this venom like directly like literally you know
farm to table type of thing so um yeah, they're going to be launching soon. And
then we're also working with the side out team. They are going to be launching probably both LSD
and psilocybin next week is the goal. And the endpoints there are on aging, because there has
been some evidence that's come out that, you know, those two molecules can actually extend lifespan. But also we're going to do some like neurological
testing, obviously. So we're going to, you know, potentially do some similar cognition tests that
we're going to do with nootropics, dows, pineal on mice. So shit's heating up, like let's freaking go it's time it's it's de-sized time let's uh we
got a job to do and uh let's take this thing to valhalla
cool anyway jelly intro like uh i feel bad like people have been off for so long uh
are you trying to wrap it up you're trying to keep riffing like what's the vibe
yo i was i was actually just searching the venom i was like wait can i get the venom
yeah it's called yeah their brand is called blue scorpion um and they're awesome like they
they're actually super well connected in crypto too.
So I think they're going to do super well.
Anyway, like obviously as a skeptical scientist,
I'm like, yo, there's no way this shit works,
but yo, we're going to run a human study
where people are wearing wearables,
taking either the venom or control
and we'll monitor their stress levels,
inflammation, sleep, et cetera, you know, stress levels, inflammation,
sleep, et cetera, et cetera, whatever we can measure from a wearable.
Um, you know, obviously if they get enough funding, we can do blood testing too.
And we can test the actual like inflammation markers.
Um, but yeah, like, let's find out, like they, they talk a big game.
I think it's good to be skeptical.
And that's kind of the whole point of what this is.
Like, do you believe in this or not?
If you believe in it and want to see the study like cool help fund it but if you don't believe
in it like you don't touch it but yeah i'm i'm super bullish regarding this because in my country
for example the bee sting the bee venom uh it's super powerful for for articulating articulators of the the g the joints for the
joints at the elder it's a treatment and there are many clinics where they can treat you with
steve beings like they bring the bees and go in the room and let them sting you.
You know, it's, it's real.
Wait, that's a clinic you can go to?
Go in a room and get stung by bees?
Yeah.
Yeah.
The last two days, these D-sized bases, we were talking to someone on an Arctic ship
last night who was like following polar bears.
And now I'm learning about bee sting clinics.
Like you.
Wait a second.
I have an idea.
If anyone rug pulls on pump science,
we're sending them to the bee sting clinic.
For sure.
In Romania.
I have it.
This is crazy.
We'll bring all of them there.
Okay.
But seriously,
like I think what is to Benji's point,
like if there is some kind of like,
you know, niche science that's happening or niche
product, like what's been cool about what we're doing now is like really trying to think about
experiments outside of just longevity experiments. So if there's something that you're, you want to
test and right now you don't know of like, uh, right now you don't see it in the way that we're
running our experiments. Don't count yourself out.
Like message our team.
And if there's a way we can find an endpoint and run a study, we will figure it out.
So be seeing studies.
Here we come.
Awesome.
Well, Alana, I don't, I think that's probably, I mean, I know we went an extra hour over.
I think you guys are known for hosting the longest spaces, the most epic spaces too.
I mean, it was, we've round tripped the whole, the whole thing. So appreciate you hosting our
community. This was so much fun. And just a reminder for folks too on the molecule side if you go to molecule.xyz you can see
the pump science tokens on the molecule d-size screener so just uh except except not pnl did
we i know we talked about a lot of on it she's hunting it down yeah anyway that was weird because
like every other token is listed but them and like the nootropic
style guys are like conspiratorial to begin with so don't give them extra reasons to be
you know conspiracy theorizing yeah i'm on it i'm on it
um okay thank you guys so much, everyone who joined the space.
And I'm super happy to have you all had and for the conversation we had.
It was super, super valuable.
Really interesting as well.
Till next time.
Till next time.
Well, we'd be excited to come back.
Just tell us when and where.
But thank you so much for opening up the space to our community.
It was a lot of fun.
Thank you so much.
Speaker
Pump Science
from
Rifampicin
