Dose of Alpha Episode #5: A.I. Skills Interview with Taariq Lewis | SerenDB
What if your AI agent could out-trade institutional desks — from your laptop?
In Episode 5 of Dose of Alpha, Bryan Colligan sits down with Taariq Lewis, founder of Seren DB and a crypto OG since 2013, to break down the "Open Claw" world: a future where locally-running AI agents autonomously research, execute, and report on trades — no middlemen, no managed accounts, no waiting on a fund.
They cover the rise of autonomous trading agents, why LLMs are powerful but untrustworthy ("they lie"), how AI is the key that finally gets grandma on-chain, and what happens to knowledge workers when agents don't need sleep.
🔑 Topics covered:
0:00 Intro to Taariq Lewis & Seren DB
1:18 From early crypto to AI Agents
3:19 The Open Claw World explained
6:05 Bypassing UI — bringing non-crypto users onchain
8:30 Skills: AI prompts as functional programs
14:10 Security risks, scams & LLMs lies
18:17 Human displacement by agents
22:31 Agent-to-agent economies & synthetic currencies
26:00 PolyMarket bots & alpha strategies
27:30 Compute-backed currencies
31:30 Smart Beta: shorting SaaS & infrastructure
38:07 Tokenizing skills for non-crypto users
40:44 How to get started with Seren
🌐 Learn more: serendb.com | 🔗 AlphaGrowth: alphagrowth.io
📲 Follow Bryan: @bryancolligan | @alphagrowth1
The AlphaGrowth team is excited to bring you real-time intel from the DeFi front lines, each week as we release new episodes. Stay tuned for more! And don't forget to comment and share your thoughts with us on YouTube, Spotify, X, Apple Podcasts. Bring RWAs onchain with AlphaGrowth in 2026: alphagrowth.io.
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